Friday 8 January 2021

Gene Editing


I was interested to read a press release today with the headline “Gene editing creates potential to protect the nation’s environment, pollinators and wildlife”.

Consultation on future of gene editing was launched by the Environment Secretary, George Eustice, at the Oxford Farming Conference today.

A section of the released statement reads:

The way that plants and animals grow is controlled by the information in their genes. For centuries, farmers and growers have carefully chosen to breed stronger, healthier individual animals or plants so that the next generation has these beneficial traits - but this is a slow process.

Technologies developed in the last decade enable genes to be edited much more quickly and precisely to mimic the natural breeding process, helping to target plant and animal breeding to help the UK reach its vital climate and biodiversity goals in a safe and sustainable way.

Gene editing is different to genetic modification where DNA from one species is introduced to a different one. Gene edited organisms do not contain DNA from different species, and instead only produce changes that could be made slowly using traditional breeding methods. But now, due to a legal ruling from the European Court of Justice in 2018 gene editing is regulated in the same way as genetic modification.

The consultation announced today will focus on stopping certain gene editing organisms from being regulated in the same way as genetic modification, as long as they could have been produced naturally or through traditional breeding. This approach has already been adopted by a wide range of countries across the world, including Japan, Australia and Argentina.

Government will continue to work with farming and environmental groups to develop the right rules and ensure robust controls are in place to maintain the highest food safety standards while supporting the production of healthier food.

Potentially, I recognise that gene editing could be a powerful tool within agriculture, offering breeders the potential to wipe out genetic disease, improve drought resistance, boost nutrient efficiency and prolong shelf life, to name but a few benefits.

But as Peter Stevenson, chief policy adviser at the campaigning group Compassion in World Farming said, “the ways in which livestock had been bred for profitable traits in the past suggested the development of gene editing would be harmful to animals. He pointed to genetic selection for broiler chickens, whereby the fast growth rates gave rise to leg abnormalities and lameness, and in laying hens, selecting for high egg production caused osteoporosis, leaving the hens vulnerable to bone fractures”.

Patrick Holden, of the Sustainable Food Trust, said gene editing would “further accelerate the devastating narrowing of the gene pool which has been a feature of post-war farming”.

I would highlight a non-agricultural example to make the decision makers think long and hard before finalising their judgment. Remember, the following has nothing to do with feeding the world, but simply a human trait for what some see as “pleasing to the eye”. Can humans really be trusted with gene editing?

A number of dog breeders have a lot to answer for in my opinion. For instance, Pug dogs are one of the most inbred of all dog breeds. Knee disorders, stomach problems, larynx collapses, elongated soft pallets and breathing problems brought about because of its squashed face are just some of the issues that affects pugs.

Other problems which pugs must put up with are, curvature of the spine and a propensity to suffer from eye injuries, largely caused by a lack of facial structure which would normally protect the dog. The spinal problems are caused by dog breeder’s desire to have a curled tail called a ‘screw tail’.

Pugs have been radically changed through selective breeding


Another example, found in a recent study, is that 70% of Cavalier King Charles Spaniels had syringomyelia by the age of six years. Syringomyelia is the formation of fluid filled cavities in the spinal cord because of abnormalities in the pressure of cerebrospinal fluid due to a mismatch between the size of the brain and the skull or with abnormality of the skull shape. This has been brought on because of the desire by dog show judges for an ever-smaller head size.

Dogs with syringomyelia can show severe signs of pain around their head, neck, and forelimbs and may whine, yelp or cry and contort their necks, become withdrawn, develop a weak or wobbling gait, such that walking becomes increasingly difficult.

Now bear in mind, these problems have been brought about by selective breeding, quite a slow process. Gene editing can fast-forward animal and plant traits extremely quickly.

If you want to find out more and have your say - go to: https://consult.defra.gov.uk/agri-food-chain-directorate/the-regulation-of-genetic-technologies/

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